Table 3.
Tissue biodistribution of radiolabeled isatin sulfonamide analogs.
| [18F]WC-4-116 | [18F]WC-4-35 | |||
|---|---|---|---|---|
| 30 min | 60 min | 30 min | 60 min | |
| Blood | 0.55 ± 0.09 (0.40,0.65) |
0.36 ± 0.07 (0.26, 0.45) |
8.07 ± 2.23 (6.0, 10.4) |
3.77 ± 0.72 (3.1, 4.5) |
| Bone | 0.27 ± 0.19 (0.14, 0.68) |
0.12 ± 0.07 (0.06, 0.27) |
1.74 ± 0.33 (1.3, 2.0) |
2.44 ± 0.41 (2.0, 3.0) |
| Brain | 0.05 ± 0.01 (0.037, 0.057) |
0.03 ± 0.01 (0.023, 0.043) |
2.20 ± 0.12 (2.0, 2.3) |
2.05 ± 0.35 (1.6, 2.4) |
| Fat | 0.49 ± 0.36 (0.20, 1.2) |
0.40 ± 0.61 (0.06, 1.9) |
2.05 ± 0.45 (1.7, 2.7) |
1.50 ± 0.55 (1.0, 2.2) |
| Heart | 0.27 ± 0.05 (0.19, 0.33) |
0.17 ± 0.05 (0.12, 0.25) |
3.87 ± 0.14 (3.8, 4.0) |
2.96 ± 0.44 (2.6, 3.4) |
| Kidney | 1.50 ± 0.33 (1.1, 2.2) |
0.41 ± 0.11 (0.26, 0.57) |
4.41 ± 0.33 (4.0, 4.8) |
2.58 ± 0.50 (2.1, 3.1) |
| Liver | 3.00 ± 0.60 (2.3, 3.8) |
0.83 ± 0.27 (0.53, 1.4) |
5.31 ± 0.47 (4.8, 5.7) |
3.48 ± 0.61 (2.5, 3.7) |
| Lung | 1.50 ± 0.37 (1.1, 1.9) |
0.83 ± 0.15 (0.7, 1.2) |
5.21 ± 0.95 (4.1, 6.3) |
3.00 ± 0.58 (2.5, 3.7) |
| Muscle | 0.34 ± 0.43 (0.15, 1.4) |
0.55 ± 0.72 (0.07, 2.2) |
2.31 ± 0.22 (2.0, 2.5) |
1.84 ± 0.28 (1.6, 2.1) |
| Spleen | 0.44 ± 0.10 (0.33, 0.60) |
0.20 ± 0.04 (0.14, 0.25) |
4.08 ± 0.36 (3.7, 4.5) |
2.72 ± 0.51 (2.3, 3.3) |
| Tumor | 0.21 ± 0.04 (0.16, 0.28) |
0.12 ± 0.03 (0.07, 0.19) |
3.13 ± 0.22 (2.9, 3.5) |
2.99 ± 0.47 (2.3, 3.8) |
| Tumor:Blood | 0.40 ± 0.09 (0.27, 0.56) |
0.58 ± 0.25 (0.27, 1.06) |
0.42 ± 0.13 (0.27, 0.56) |
0.80 ± 0.13 (0.69, 1.06) |
|
| ||||
| N=4 for brain N=8 all other organs N=16 tumors |
N=4 for brain N=8 other organs N=16 tumors |
N=4 organs N=8 tumors |
N=4 organs N=8 tumors |
|
All values are % injected dose per gram of tissue (%ID/g), represented as mean ± standard deviation (minimum, maximum), except for the bottom row showing the tumor:blood ratio as indicated.