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. 2016 Mar 4;127(20):2489–2497. doi: 10.1182/blood-2015-12-688895

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© 2016 by The American Society of Hematology

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cTFH signature correlates with plasmablast generation in patients with cGVHD (N = 38). (A) Correlation between number of activated cTFH (ICOS^hiPD-1^hi CXCR5⁺CD45RA⁻CD4⁺ T cells) and number of circulating CD27⁺ B cells in patient samples. (B) Correlation between cTFH proliferation (%Ki67) and percentage of plasmablasts (CD27^hiCD38^hi) in patient samples. (C) Correlation between proliferation (%Ki67) of CXCR3⁻ cTFH and percentage of plasmablasts (CD27^hiCD38^hi) in patient samples. (D) Correlation between number of activated cTFH (ICOS^hiPD-1^hi) and number of plasmablasts (CD27^hiCD38^hi) in patient samples. (E) Correlation between percentage of activated CXCR3⁻ cTFH (ICOS^hiPD-1^hi) and number of plasmablasts (CD27^hiCD38^hi) in patient samples. The Spearman test was used.