Table 1.

Ingenuity Analysis of Subgroup-Specific Genes in Medulloblastoma

Ingenuity Canonical Pathways	P	Molecules
WNT
Axonal guidance signaling	< .001	EPHA7, FZD10, BMP4, WNT16, EPHA4, NFATC4, SLIT2, EPHA3, ADAM12, PRKCD, FZD6, ADAM19, PLCB1, SEMA3B
WNT/β-catenin signaling	< .001	FZD10, AXIN2, WIF1, FZD6, DKK4, WNT16, DKK2, LEF1, KREMEN1, DKK1
Factors promoting cardiogenesis in vertebrates	.00339	FZD10, BMP4, PRKCD, FZD6, LEF1, DKK1
O-glycan biosynthesis	.00417	GLT8D2, GALNT7, GALNT14, GALNT12, GALNTL2
Basal cell carcinoma signaling	.00776	FZD10, BMP4, FZD6, WNT16, LEF1
SHH
SHH signaling	< .001	DYRK1B, ARRB2, GLI2, GLI3, HHIP, GLI1, PTCH2
Basal cell carcinoma signaling	< .001	TP53, GLI2, GLI3, LEF1, HHIP, GLI1, BMP5, FZD7, PTCH2
WNT/β-catenin signaling	< .001	TP53, SFRP4, TCF4, HDAC1, SOX2, SOX9, RARB, TGFB2, SFRP5, PPP2R2C, LEF1, SFRP1, TCF7L2 (includes EG:6934), FZD7
Axonal guidance signaling	< .001	GLI2, PLXNC1, CXCR4, SEMA6A, GNG3, HHIP, NFATC4, BMP5, ROBO1, PTCH2, PLCB4, GLI3, SRGAP1, SDC2, NTRK3, NGFR, EFNA5, ABLIM3, PDGFD, GLI1, PRKD1, FZD7, UNC5C
Human embryonic stem-cell pluripotency	.00295	SOX2, NTRK3, PDGFRA, SPHK1, TGFB2, LEF1, PDGFD, BMP5, FZD7
Group C
Phototransduction pathway	< .001	GNB3, GNGT1, RCVRN, PDE6H
WNT/β-catenin signaling	.00933	MYC, NLK, TGFB1, TGFBR3, PPP2R2B
Glutamate receptor signaling	.01122	GNB3, SLC17A7, SLC1A7
Thyroid cancer signaling	.04074	MYC, RXRG
p38 MAPK signaling	.04266	MYC, TGFB1, EEF2K
Group D
Semaphorin signaling in neurons	< .001	ARHGEF12, RND1, RHOT1, DPYSL4, DIRAS3, FNBP1
cAMP-mediated signaling	.00275	GRK4, GRM8, RGS7, ADCY1, STAT3, PDE4B, AKAP9, CHRM3, PDE1C
G protein–coupled receptor signaling	.00490	HTR2C, GRK4, GPR12, GRM8, RGS7, ADCY1, STAT3, PDE4B, CHRM3, PDE1C
p53 signaling	.00603	KAT2B, CCND2, GADD45G, C12ORF5, HIPK2, TP53BP2
Cardiac β-adrenergic signaling	.00617	ADCY1, CACNA1C, PDE4B, GNG2, AKAP9, CACNA1A, PDE1C

Abbreviation: MAPK, mitogen-activated protein kinase; cAMP, cyclic adenosine monophosphate.