Table 2.
Group C Versus Group D Medulloblastoma
| Genotype/Phenotype | Group C |
Group D |
P | ||
|---|---|---|---|---|---|
| No. | Total No. | No. | Total No. | ||
| Demographics | |||||
| Infant (MB103/TMA) | 10 | 106 | 8 | 114 | NS |
| Child (MB103/TMA) | 94 | 106 | 91 | 114 | NS |
| Adult (MB103/TMA) | 2 | 106 | 15 | 114 | .0018 |
| Gene expression | |||||
| MYC expression (mean signal intensity exon array) | 9.424 | 6.787 | < .001 | ||
| NPR3 expression (mean signal intensity exon array) | 9.195 | 6.280 | < .001 | ||
| KCNA1 expression (mean signal intensity exon array) | 6.812 | 10.702 | < .001 | ||
| NPR3 positive (TMA) | 80 | 80 | 0 | 80 | < .001 |
| KCNA1 positive (TMA) | 0 | 80 | 80 | 80 | < .001 |
| Genetics | |||||
| 1q gain (SNP array) | 12 | 27 | 3 | 35 | .0021 |
| 5q loss (SNP array) | 6 | 27 | 2 | 35 | .0689 |
| 10q loss (SNP array) | 7 | 27 | 1 | 35 | .0168 |
| i(17)q (SNP array) | 7 | 27 | 23 | 35 | .0024 |
| MYC amplification (SNP array/FISH) | 11 | 98 | 0 | 98 | < .001 |
| MYCN amplification (SNP array/FISH) | 8 | 98 | 6 | 98 | NS |
| Histology | |||||
| Classic (TMA-DKFZ) | 54 | 71 | 56 | 63 | .0708 |
| Desmoplastic (TMA-DKFZ) | 1 | 71 | 2 | 63 | NS |
| Large cell/anaplastic (TMA-DKFZ) | 16 | 71 | 5 | 63 | .0306 |
| Outcome | |||||
| M+ (TMA-DKFZ) | 33 | 71 | 19 | 64 | .0527 |
| PFS (TMA-DKFZ), % | 32 | 63 | < .001 | ||
| OS (TMA-DKFZ), % | 33 | 77 | < .001 | ||
Abbreviations: MB, medulloblastoma; TMA, tissue microarray; NS, not significant; SNP, single nucleotide polymorphism; FISH, fluorescent in situ hybridization; DKFZ, German Cancer Research Center; PFS, progression-free survival; OS, overall survival.