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. Author manuscript; available in PMC: 2016 May 20.
Published in final edited form as: Trends Cancer. 2016 Mar;2(3):134–143. doi: 10.1016/j.trecan.2016.02.005

Figure 1. Role of microRNAs in CLL pathogenesis.

Figure 1

miR-15/16 deletion results in Bcl2 and Mcl1 overexpression leading to B-cell transformation. Down-regulation of miR-181 and miR-3676 causes Tcl1 overexpression, increased Akt activity and inhibition of de novo DNA methylation. miR-155 up-regulation causes B-cell malignancies through the targeting of SHIP1.