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. Author manuscript; available in PMC: 2016 Oct 7.
Published in final edited form as: J Am Chem Soc. 2015 Sep 23;137(39):12498–12501. doi: 10.1021/jacs.5b08582

Figure 2.

Figure 2

Demonstration that monomer 8 is capable of supporting the self-propagating reaction. (a) The reaction conditions and products when 8 is exposed to thiol (cysteine in this example). (b) LCMS chromatograms that reveal the temporal change in concentration of reactants and products when 8 (2 mM) in 1:1 MeCN–buffered water (pH 7.4) is exposed to 0.1 equiv of l-cysteine at 23 °C. (c) Kinetics (obtained from fluorescence measurements) that support the self-propagating reaction in (a). These results demonstrate that even trace levels of added thiol elicit a maximum fluorescence response over time. The graph includes all data corresponding to three replicates per equivalent of added cysteine. The inset clarifies the response for 1 equiv of cysteine. The λex for coumarin 11 is 320 nm, while the λem is 380 nm. The lines are simulated data for the reaction A + B → C + A (see the text for details) superimposed on the experimental data points.