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. 2016 Apr 19;5(5):563–570. doi: 10.1242/bio.015008

Fig. 3.

Fig. 3.

miR-204 facilitates the inhibitory effect of 5-Fu on CRC cell lines. (A) CRC cell proliferation was examined under conditions of miR-204 overexpression by miR-204 mimic transfection or HMGA2 inhibition by si-HMGA2 without 5-Fu treatment to verify the role of miR-204/HMGA2 in CRC cell growth. Results showed that proliferation of both HCT116 and SW480 cell lines were inhibited by miR-204 overexpression or HMGA2 inhibition compared with null-transfected cell lines. (B) Under a dose-dependent 5-Fu treatment at concentrations of 2, 4, 16, 32 and 64 μg/ml, proliferation levels of miR-204 mimic-transfected CRC cell lines were examined. Results showed that cell inhibition rate of HCT116 and SW480 cell lines increased with 5-Fu dose, and the cell inhibition rate of miR-204 mimic-transfected CRC cell lines was higher compared with null-transfected cell lines. Figure is representative of three experiments with similar results. Data represented as means±s.d.; *P<0.05, **P<0.01 by one-way ANOVA.