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Antigen-pulsed CLIC1−/− BMDCs have a reduced capacity to activate CD4+ T-cells. The proportion of activated (intracellular IFNγ-containing) MOG-specific 2D2 CD4+ T-cells after 16 h coculture with BMDCs pulsed with (A) 1.25 pmoles of the short MOG35-55 peptide or (B) with equimolar full length MOG1-125. The fold increase in activated T-cells was calculated relatively to the no antigen control. Data, representing mean±s.e.m., were analysed using two-way repeated-measures ANOVA.
