Outline of the computational approach. The model parameters are T0 (initial target cell density), k (rate of transition from latently infected to productively infected cells), γ (WNV clearance rate), V0 (inoculated virus density), β (rate constant of infection), δ (death rate of productively infected cells), p (infectious virus production rate), ρ (efficacy of antibody neutralization) and ti (time of initiation of the IgM response).