Table 2.

Imposed biological constraints and estimated output ranges, mean and standard deviation of model parameters. V₀, inoculated virus density (PFU ml⁻¹); β, rate constant of infection (ml day⁻¹); δ, death rate of productively infected cells (day⁻¹); p, infectious virus production rate (day⁻¹); ρ, efficacy of antibody neutralization (); t_i, time of initiation of the IgM response (days post-infection); R₀, basic reproductive number (equation (3.1)); p/δ, infectious burst size (average number of infectious virus particles produced over the lifetime of an infected cell, PFU).

statistic	V0	β	δ	p	ρ	ti	R0	p/δ
imposed constraint	[10−4, 3.3 × 103]	[10−5, 10−2]	[0.3, 24]	[0.3, 120]	[1, 60]	[2, 4]	[1, 30]	[1, 30]
estimated range	[0.01, 3.3 × 103]	[2 × 10−4, 9 × 10−3]	[1.7, 24]	[5.2, 118.2]	[2.1, 60]	[3.1, 3.9]	[1.4, 7.1]	[1.7, 12.8]
mean ± s.d.	5 ± 4	1.3 × 10−3 ± 1.8	11.8 ± 1.7	32.8 ± 1.6	28.2 ± 18.3	3.6 ± 0.1	2.3 ± 0.3	2.9 ± 1