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. 2016 Apr;13(117):20160167. doi: 10.1098/rsif.2016.0167

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© 2016 The Author(s)

Published by the Royal Society. All rights reserved.

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Figure 1. — Comparison of the agent-based fluctuation and oscillation model. (a) Network scheme of the fluctuation model. The negative regulation of Nanog by Fgf4/Erk captures mESCs in a bistable setting. The repression rate is termed p; transcription rates are denoted by s_i. (b) Stochastic fluctuations between the NH and the NL state of one simulated cell and its progeny. (c) Bimodal Nanog and Rex1 distributions of a simulated cell population adapted to flow cytometry data of Rex1GFPd2 mESCs (grey histogram). (d) Network scheme of the oscillation model. The negative feedback loop between Nanog and Fgf4/Erk generates sustained oscillations. (e) Oscillations between NH and NL levels of one simulated cell and its progeny. (f) Bimodal Nanog and Rex1 distributions of a simulated cell population adapted to flow cytometry data of Rex1GFPd2 mESCs (grey histogram). (Online version in colour.)