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. Author manuscript; available in PMC: 2016 May 20.
Published in final edited form as: Nature. 2015 Mar 4;519(7544):431–435. doi: 10.1038/nature14285

Extended Data Figure 6. Cartoon illustrating protein kinase regulated eukaryotic DNA replication origin firing with purified proteins.

Extended Data Figure 6

Firing factors are recruited to loaded MCM in a DDK- and CDK-dependent manner. DNA synthesis is initiated once the DNA template has been unwound. CDK also functions to inhibit MCM loading by phosphorylating ORC.