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. 2016 May 15;143(10):1710–1720. doi: 10.1242/dev.127647

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© 2016. Published by The Company of Biologists Ltd

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Fig. 3. — Tnks regulates ISC proliferation but not differentiation during homeostasis. MARCM clones (marked by GFP) of indicated genotypes, stained with anti-GFP (green) and DAPI. Tnks¹⁹ flies (B) have increased number of multi-cell clones compared with wild-type flies (A). (C) Quantification of clone size for wild-type, Tnks¹⁹ or pygo^S123 ISC lineages in posterior midguts. Number of clones examined is indicated. (D-F) Tnks mutant ISCs can give rise to transient undifferentiated EBs (arrow). Tnks¹⁹ clones are marked by GFP (green) and EBs by Su(H)-lacZ (magenta). (G-I) Tnks mutant ISCs can differentiate into ECs (arrow). (J-L) Tnks mutant ISCs can differentiate into EE cells (arrow). Clones were induced in adults on the day of eclosion and analyzed 4 days later. Scale bars: 10 μm.