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. 2016 May 15;143(10):1811–1822. doi: 10.1242/dev.131722

Fig. 4.

Fig. 4.

Increased expression of Fgf9 and Fgf18 in Osx-Cre;DCKO mice. (A) Expression of Fgf9, assessed by in situ hybridization, in proximal tibia of P21 mice showing increased expression in the perichondrium, reserve, proliferating and prehypertrophic chondrocytes of Osx-Cre;DCKO mice. (B) qRT-PCR analysis of Fgf9 expression in DFF and Osx-Cre;DCKO proximal tibia metaphysis (n=3). (C) Expression of Fgf18, assessed by situ hybridization, in P21 proximal tibia showing increased expression in articular cartilage, proliferating and prehypertrophic chondrocytes in the growth plate and in trabecular bone of Osx-Cre;DCKO mice. (D) qRT-PCR analysis of Fgf18 expression in DFF and Osx-Cre;DCKO proximal tibia metaphysis (n=3). rc, reserve chondrocytes; p, proliferating chondrocytes; h, hypertrophic chondrocytes; ac, articular chondrocytes; tb, trabecular bone; pc, perichondrium. Error bars, s.d.; *P<0.05, **P<0.002. Scale bars: 100 µm