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. 2016 May 15;143(10):1811–1822. doi: 10.1242/dev.131722

Fig. 5.

Fig. 5.

Increased Fgfr3 expression and signaling in Osx-Cre;DCKO mice. (A,C) Expression, assessed by in situ hybridization, of Fgfr3 (A) and Snail1 (C) in DFF and Osx-Cre;DCKO distal femur. (B) qRT-PCR analysis of Fgfr3 expression in DFF and Osx-Cre;DCKO proximal tibia and distal femur metaphysis (n=3). (D) Immunohistochemistry of DFF and Osx-Cre;DCKO proximal tibia showing mildly increased SOX9 in Osx-Cre;DCKO compared with DFF mice. p, proliferating chondrocytes; h, hypertrophic chondrocytes; tb, trabecular bone. Error bars, s.d.; *P<0.05. Scale bars: 100 µm.