Table 3.

Summary of Metabolomics Analysis

Canonical Pathways	p-value	Overlap
tRNA Charging	5.20 × 10−7	20.9 % (9/43)
Alanine Degradation III	6.23 × 10−5	75.0 % (3/4)
Alanine Biosynthesis II	6.23 × 10−5	75.0 % (3/4)
Glutamate Degradation II	3.01 × 10−4	50.0 % (3/6)
Renal Cell Carcinoma Signaling	6.50 × 10−4	100.0 % (2/2)

Diseases and Bio Functions	p-value	Metabolites
Cancer	4.81 × 10−2 - 1.09 × 10−7	13
Gastrointestinal Disease	4.81 × 10−2 - 1.09 × 10−7	14
Hepatic System Disease	4.81 × 10−2 - 1.09 × 10−7	9
Organismal Injury and Abnormalities	4.95 × 10−2 - 1.09 × 10−7	18
Metabolic Disease	4.81 × 10−2 - 2.33 × 10−4	11

Molecular and Cellular Functions	p-value	Metabolites
Cellular Growth and Proliferation	4.81 × 10−2 - 7.00 × 10−6	10
Small Molecule Biochemistry	4.95 × 10−2 - 3.91 × 10−6	21
Cellular Function and Maintenance	4.95 × 10−2 - 2.71 × 10−6	16
Amino Acid Metabolism	4.81 × 10−2 - 3.91 × 10−6	12
Carbohydrate Metabolism	4.81 × 10−2 - 2.71 × 10−5	11

Toxicology Functions
Clinical Chemistry and Hematology	p-value	Metabolites
Increased Levels of Albumin	4.36 × 10−6 - 4.36 × 10−6	5
Increased Levels of LDH	4.21 × 10−1 - 9.40 × 10−2	3
Increased Levels of Alkaline Phosphatase	4.81 × 10−2 - 4.81 × 10−2	1
Increased Levels of Blood Urea Nitrogen	9.40 × 10−2 - 9.40 × 10−2	1
Increased Levels of ALT	1.16 × 10−1 - 1.16 × 10−1	1

Nephrotoxicity	p-value	Metabolites
Renal Damage	4.81 × 10−2 - 2.56 × 10−3	4
Kidney Failure	4.36 × 10−1 - 4.95 × 10−2	3
Renal Degeneration	2.44 × 10−2 - 2.44 × 10−2	1
Renal Tubule Injury	4.81 × 10−2 - 4.81 × 10−2	1
Nephrosis	9.40 × 10−2 - 9.40 × 10−2	1

Top molecules	Fold change
D-mannose	⇑ 3.205
acetyl-L-carnitine	⇑ 2.524
D-pantothenic acid	⇑ 1.913
fumaric acid	⇑ 1.883
malic acid	⇑ 1.881
pyruvic acid	⇑ 1.717
L-aspartic acid	⇑ 1.559
glycerol	⇑ 1.485
L-tryptophan	⇑ 1.445
L-methionine	⇑ 1.404