Table 2.

Associations between various allergy types and glioma risk: Results from the Glioma International Case-Control Study (GICC)

	Case		Control		Adjusted Meta-Analysis Odds Ratios (95% Confidence Intervals)a			Heterogeneity Test
	N	%	N	%				I2 (%)	Tau2	P-value
Animal/insect allergiesb								59.30	0.0761	0.0063
No	3783	85.55	3407	86.08	1.00
Yes	639	14.45	551	13.92	0.98	0.80	1.21
Food allergiesb								66.10	0.1411	0.0011
No	4038	91.11	3540	89.17	1.00
Yes	394	8.89	430	10.83	0.78	0.59	1.03
Medication allergies								68.90	0.1004	0.0001
No	3443	77.91	3147	79.41	1.00
Yes	976	22.09	816	20.59	0.98	0.80	1.21
Soap/cosmetics allergiesc								75.50	0.2607	<0.0001
No	4098	92.82	3629	91.83	1.00
Yes	317	7.18	323	8.17	0.79	0.55	1.12

^aFull two-stage random-effect restricted maximum likelihood model adjusting for glioma diagnosis/enrollment age and sex.

^bCase Western and USC excluded from meta-analysis due to cell frequencies <5.

^cBrigham and Women’s, Case Western, and USC excluded from meta-analysis due to cell frequencies <5.