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. Author manuscript; available in PMC: 2017 May 15.
Published in final edited form as: J Immunol. 2016 Apr 18;196(10):4040–4051. doi: 10.4049/jimmunol.1502276

FIGURE 7. Working model for pathogenesis of de novo autoimmune hepatitis.

FIGURE 7

Two dominant cytokine clusters - the IL-12-IFN-γ axis and the IL-6-IL-17 axis contribute to de novo autoimmune hepatitis. Monocytes drive differentiation towards a TH1-like Treg phenotype through IL-12 secretion. The resulting pro-inflammatory milieu leads to paralysis of regulatory function.