Figure 10.
A model for CaSR-mediated regulation of IMI voltage dependence. According to this model, IMI channels are activated by a neuropeptide receptor using a pathway (not shown here) independent from the depicted voltage dependence pathway. The voltage dependence of IMI is regulated by G-protein-coupled CaSRs. Calmodulin (CaM) stabilizes the receptor on the membrane, and inhibitors of calmodulin lead to CaSR endocytosis. Green boxes and blunt-ended lines show agents that inhibit the indicated paths. Arrows indicate activating pathways. Intracellular calcium release via ryanodine receptors is part of the source for calmodulin activation, and both CaMKII and MLCK inhibit voltage dependence.