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. 2016 May 12;3(2):ENEURO.0038-16.2016. doi: 10.1523/ENEURO.0038-16.2016

Figure 8.

Figure 8.

The endocytosis inhibitor dynasore prevents W7-induced increases in IMI slope in LP neurons. CCAP-induced IMI was measured before (black) and after exposure to the following: 33 µm W7 for 45-65 min (red); dynasore for 45-80 min (blue); 20 min in 33 µm dynasore, then 45-60 min in 33 µm dynasore plus 33 µm W7 (green). A, Representative I–V curves of W7 effect (top) and dynasore effect (bottom). B, Average I–V curves of all experiments. C, Average slope of CCAP-induced IMI from data in B and two-way ANOVA for the effects of factors dynasore and W7 on slope (W7: F(1,32) = 14.934, p = 5.12 × 10−4; dynasore: F(1,32) = 4.317, p = 0.046; Interaction: F(1,32) = 2.109, p = 0.156ae). Post hoc Tukey’s comparisons on slope: (1) W7 only vs control (p < 0.001); (2) dynasore only vs control (p = 0.624); (3) dynasore only vs dynasore plus W7 (p = 0.129); and (4) W7 only vs W7 plus dynasore (p = 0.03). Post hoc Tukey’s test: *p < 0.05; ***p < 0.001.