Table 3:
Drug name | [Drug] | [Ca] | Neuromodulator | n | IMI slope (nS) |
---|---|---|---|---|---|
W7 | 0 µm | 13 mm | Proctolin | 12 | −21.7 ± 3.7 |
0.1 µm | 13 mm | Proctolin | 5 | −13.5 ± 4.2 | |
1 µm | 13 mm | Proctolin | 6 | −11.2 ± 2.4* | |
10 µm | 13 mm | Proctolin | 6 | −11.4 ± 3.9** | |
100 µm | 13 mm | Proctolin | 6 | +13.1 ± 3.4*** | |
Calmidazolium | 0 µm | 13 mm | Proctolin | 6 | −20.4 ± 10.6 |
0.1 µm | 13 mm | Proctolin | 2 | −13.7 ± 11.1 | |
0.3 µm | 13 mm | Proctolin | 6 | +1.6 ± 14 | |
0.0 µm | 13 mm | Proctolin | 4 | +4.3 ± 4.9 | |
Dantrolene | 0 µm | 13 mm | Proctolin | 6 | −8.1 ± 3.2 |
3.3 µm | 13 mm | Proctolin | 6 | +1.6 ± 1.9** | |
CALP1 | 0 µm | 2 mm | Proctolin | 11 | +18.2 ± 4.9 |
1 µm | 2 mm | Proctolin | 4 | +10.2 ± 6.4 | |
10 µm | 2 mm | Proctolin | 4 | +28.2 ± 3.8 | |
50 µm | 2 mm | Proctolin | 2 | +23.5 ± 9.4 | |
KN-93 | 0 µm | 13 mm | Proctolin | 7 | −21 ± 4.2 |
Low dose | 13 mm | Proctolin | 5 | +0.8 ± 5.8 | |
High dose | 13 mm | Proctolin | 2 | +16.6 ± 2.2 | |
Pertussis toxin | 0 µg/ml | 13 mm | Proctolin | 7 | −3.1 ± 2.9 |
0 µg/ml | 2 mm | Proctolin | 6 | +14.4 ± 3.1 | |
10 µg/ml | 13 mm | Proctolin | 7 | +1.5 ± 2.9 | |
10 µg/ml | 2 mm | Proctolin | 6 | +21.5 ± 3.1 | |
GTPγS | 0 mm | 13 mm | Proctolin | 9 | −2.2 ± 2.9 |
0 mm | 2 mm | Proctolin | 8 | +11.5 ± 3.1 | |
10 mm | 13 mm | Proctolin | 5 | −6.7 ± 4.0 | |
10 mm | 2 mm | Proctolin | 4 | +15.2 ± 4.4 | |
Gallein | 0 µm | 13 mm | Proctolin | 9 | −5.4 ± 1.6 |
1 µm | 13 mm | Proctolin | 9 | +1.5 ± 1.9* | |
3 µm | 13 mm | Proctolin | 9 | +0.7 ± 2.8 | |
ML-7 | 0 µm | 13 mm | Proctolin | 12 | −4.2 ± 1.5 |
0.1 µm | 13 mm | Proctolin | 12 | +1.7 ± 2.3* | |
1 µm | 13 mm | Proctolin | 10 | +4.5 ± 1.4*** | |
10 µm | 13 mm | Proctolin | 7 | +3.1 ± 2.4* | |
Dynasore, W7 | 0, 0 µm | 13 mm | CCAP | 18 | −11.3 ± 1.3 |
0, 33 µm | 13 mm | CCAP | 6 | −0.4 ± 2.3*** | |
33, 0 µm | 13 mm | CCAP | 6 | −12.6 ± 2.3 | |
33, 33 µm | 13 mm | CCAP | 6 | −7.7 ± 2.3† | |
R568 | 0 µm | 13 mm | Proctolin | 10 | −0.7 ± 4.5 |
0 µm | 2 mm | Proctolin | 6 | +16.5 ± 5.9 | |
10 µm | 13 mm | Proctolin | 4 | +17.3 ± 7.2* | |
10 µm | 2 mm | Proctolin | 4 | +36.9 ± 7.2‡ |
Data are reported as the mean ± SEM. All data were obtained from LP neurons.
Tukey’s test/t test p value vs control: *p < 0.05, **p < 0.01, ***p < 0.001; †p < 0.05 vs W7 alone; ‡p < 0.05 vs low-calcium control.