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. 2016 May 12;3(2):ENEURO.0038-16.2016. doi: 10.1523/ENEURO.0038-16.2016

Table 3:

Drugs that affected IMI slope

Drug name [Drug] [Ca] Neuromodulator n IMI slope (nS)
W7 0 µm 13 mm Proctolin 12 −21.7 ± 3.7
0.1 µm 13 mm Proctolin 5 −13.5 ± 4.2
1 µm 13 mm Proctolin 6 −11.2 ± 2.4*
10 µm 13 mm Proctolin 6 −11.4 ± 3.9**
100 µm 13 mm Proctolin 6 +13.1 ± 3.4***
Calmidazolium 0 µm 13 mm Proctolin 6 −20.4 ± 10.6
0.1 µm 13 mm Proctolin 2 −13.7 ± 11.1
0.3 µm 13 mm Proctolin 6 +1.6 ± 14
0.0 µm 13 mm Proctolin 4 +4.3 ± 4.9
Dantrolene 0 µm 13 mm Proctolin 6 −8.1 ± 3.2
3.3 µm 13 mm Proctolin 6 +1.6 ± 1.9**
CALP1 0 µm 2 mm Proctolin 11 +18.2 ± 4.9
1 µm 2 mm Proctolin 4 +10.2 ± 6.4
10 µm 2 mm Proctolin 4 +28.2 ± 3.8
50 µm 2 mm Proctolin 2 +23.5 ± 9.4
KN-93 0 µm 13 mm Proctolin 7 −21 ± 4.2
Low dose 13 mm Proctolin 5 +0.8 ± 5.8
High dose 13 mm Proctolin 2 +16.6 ± 2.2
Pertussis toxin 0 µg/ml 13 mm Proctolin 7 −3.1 ± 2.9
0 µg/ml 2 mm Proctolin 6 +14.4 ± 3.1
10 µg/ml 13 mm Proctolin 7 +1.5 ± 2.9
10 µg/ml 2 mm Proctolin 6 +21.5 ± 3.1
GTPγS 0 mm 13 mm Proctolin 9 −2.2 ± 2.9
0 mm 2 mm Proctolin 8 +11.5 ± 3.1
10 mm 13 mm Proctolin 5 −6.7 ± 4.0
10 mm 2 mm Proctolin 4 +15.2 ± 4.4
Gallein 0 µm 13 mm Proctolin 9 −5.4 ± 1.6
1 µm 13 mm Proctolin 9 +1.5 ± 1.9*
3 µm 13 mm Proctolin 9 +0.7 ± 2.8
ML-7 0 µm 13 mm Proctolin 12 −4.2 ± 1.5
0.1 µm 13 mm Proctolin 12 +1.7 ± 2.3*
1 µm 13 mm Proctolin 10 +4.5 ± 1.4***
10 µm 13 mm Proctolin 7 +3.1 ± 2.4*
Dynasore, W7 0, 0 µm 13 mm CCAP 18 −11.3 ± 1.3
0, 33 µm 13 mm CCAP 6 −0.4 ± 2.3***
33, 0 µm 13 mm CCAP 6 −12.6 ± 2.3
33, 33 µm 13 mm CCAP 6 −7.7 ± 2.3†
R568 0 µm 13 mm Proctolin 10 −0.7 ± 4.5
0 µm 2 mm Proctolin 6 +16.5 ± 5.9
10 µm 13 mm Proctolin 4 +17.3 ± 7.2*
10 µm 2 mm Proctolin 4 +36.9 ± 7.2‡

Data are reported as the mean ± SEM. All data were obtained from LP neurons.

Tukey’s test/t test p value vs control: *p < 0.05, **p < 0.01, ***p < 0.001; †p < 0.05 vs W7 alone; ‡p < 0.05 vs low-calcium control.