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. 2016 May 20;11(5):e0155994. doi: 10.1371/journal.pone.0155994

Table 4. Association between BMI, serum lipid levels and dyslipidaemia and the probability of different levels of AST/ALT ratio1,2,3.

AST/ALT ratio
T1 (n = 152) T2 (n = 108) T3 (n = 154) P
Gender- and age- BMI (kg/m2), ≥25 vs. <25 (ref.)
    1Gender- and age-adjusted 1.00 (ref.) 0.44 (0.24–0.81)** 0.43 (0.25–0.74)** 0.003
    2Additionally adjusted
IFG (mg/dL), ≥100 vs. <100 (ref.)
    1Gender- and age-adjusted 1.00 (ref.) 0.53 (0.18–1.55)ns 0.51 (0.20–1.33)ns 0.294
    2Additionally adjusted 1.00 (ref.) 0.61 (0.21–1.83)ns 0.59 (0.22–1.57)ns 0.494
TChol (mg/dL), ≥200 vs. <200 (ref.)
    1Gender- and age-adjusted 1.00 (ref.) 0.61 (0.31–1.17)ns 0.40 (0.21–0.76)** 0.017
    2Additionally adjusted 1.00 (ref.) 0.60 (0.31–1.17)ns 0.39 (0.20–0.75)** 0.017
LDL-chol (mg/dL), ≥130 vs. <130 (ref.)
    1Gender- and age-adjusted 1.00 (ref.) 0.41 (0.19–0.88)* 0.25 (0.11–0.55)** 0.001
    2Additionally adjusted 1.00 (ref.) 0.42 (0.19–0.91)* 0.26 (0.12–0.57)** 0.002
Non-HDL-chol (mg/dL), ≥145 vs. <145 (ref.)
    1Gender- and age-adjusted 1.00 (ref.) 0.43 (0.23–0.78)** 0.33 (0.19–0.58)*** <0.001
    2Additionally adjusted 1.00 (ref.) 0.46 (0.25–0.85)* 0.36 (0.20–0.63)*** 0.001
HDL-chol (mg/dL), ≤40 vs. >40 (ref.)
    1Gender- and age-adjusted 1.00 (ref.) 0.42 (0.23–0.74)** 0.41 (0.24–0.68)** 0.001
    2Additionally adjusted 1.00 (ref.) 0.48 (0.26–0.86)* 0.47 (0.27–0.80)** 0.007
TG (mg/dL), ≥100/130 vs. <100/130 (ref.)3
    1Gender- and age-adjusted 1.00 (ref.) 0.46 (0.28–0.78)** 0.23 (0.14–0.38)*** <0.001
    2Additionally adjusted 1.00 (ref.) 0.51 (0.30–0.87)* 0.25 (0.15–0.42)*** <0.001
RPL-chol (mg/dL), ≥24.8/27.0 vs. <24.8/27.0 (ref.)4
    1Gender- and age-adjusted 1.00 (ref.) 0.29 (0.16–0.54)*** 0.21 (0.12–0.37)*** <0.001
    2Additionally adjusted 1.00 (ref.) 0.33 (0.18–0.60)*** 0.23 (0.13–0.41)*** <0.001
No. dyslipidaemia components, ≥1 vs. <1 (ref.)
    1Gender- and age-adjusted 1.00 (ref.) 0.35 (0.21–0.59)*** 0.27 (0.17–0.44)*** <0.001
    2Additionally adjusted 1.00 (ref.) 0.37 (0.22–0.63)*** 0.29 (0.18–0.48)*** <0.001

Abbreviations: OR, odds ratio; CI, confidence interval; BMI, body mass index; IFG, impaired fasting glucose; TChol, total cholesterol; LDL-chol, low-density lipoprotein cholesterol; HDL-chol, high-density lipoprotein cholesterol; non-HDL-chol, non-high-density lipoprotein cholesterol; TG, tryglicerides; RLP-chol, remnant-like particle cholesterol.

1,2 Logistic regression analysis considering the effect of one explanatory variable after adjustment for childrens’ 1gender and age (continuous variable), and 2BMI (continuous variable).

3 TG levels were categorised as <100 or ≥100 in children aged ≤9 years, and as <130 or ≥130 in children aged 10 years.

4 High RLP-chol levels were defined as ≥P75 for boys (24.8 mg/dL) and girls (27.0 mg/dL) separately.

* P<0.05

** P<0.01

*** P<0.001

ns: not significant.