Fig 8. Effect of synaptic parameter changes on network activity.

(A) Maximum of the Kolmorov-Smirnov test statistics (D_KS) comparing the three experimental and simulated distributions (black) and standard deviation of the simulated membrane potential (gray) for different GABA_A reversal potentials. Each data point is the mean ± SEM over several values of input currents. The black line denotes the D_KS limit of 0.4 above which differences become significant (p ≤ 0.05), and the gray line marks the average of the experimentally observed standard deviations (cf. Fig 4A). (B) D_KS values as a function of percent change in overall synaptic peak conductances between pyramidal cells (E) and interneurons (I). The dotted line denotes the critical D_KS value of 0.4 (see above). (C) D_KS values for different values of the standard deviation of the synaptic peak conductances using either the original log-normal distribution (gray curve) or a Gaussian distribution with the same mean and standard deviation (black curve). As above, the dotted line marks the critical D_KS value of 0.4. In all figures, each data point shows the mean ± SEM over the D_KS values for a number of different input currents.