Table 1. Sociodemographic and clinical characteristics of HIV-1 infected individuals.
| Rapid progressors | Classic progressors | Viremic Slow Progressors | Aviremic Slow Progressors | p | |
|---|---|---|---|---|---|
| Characteristics | (n = 13) | (n = 17) | (n = 7) | (n = 6) | |
| Age at first visit | 34 ± 7 | 38 ± 8 | 46 ± 7 | 44 ± 11 | 0.0051 |
| Sex (male/female) | 12/1 | 17/0 | 7/0 | 3/3 | 0.0025 |
| Race (Caucasian/other) | 12/2 | 16/1 | 6/1 | 5/1 | ns |
| Route of transmission | 8 MSM, 3 HS, 1IDU | 16 MSM, 1 IDU | 7 MSM | 3 MSM 3 HS | 0.045 |
| CD4+ T cell count (cells/mm3) | |||||
| Acute phase | 533 ± 140 | 781 ± 213 | na | na | 0.002 |
| Early phase | 446 ± 146 | 714 ± 186 | na | na | 0.0008 |
| Chronic phase | 400 ± 152 | 629 ± 244 | 562 ± 122 | 888 ± 122 | 0.0112 |
| Nadir | 255 ± 118 | 431 ± 141 | 506 ± 129 | 506 ± 175 | 0.00053 |
| Viral load (x 103) | |||||
| Acute phase | 366 ± 705 | 76.2 ± 126 | na | na | NS |
| Early phase | 121 ± 186 | 71.2 ± 108 | na | na | NS |
| Chronic phase | 7.65 ± 15 | 37.7 ± 62 | 3.01 ± 1.9 | <0.054 | 0.0035 |
| Peak | 570 ± 808 | 202 ± 236 | 8.47 ± 6.46 | 0.06 ± 0.03 | 0.00016 |
Age, CD4 and viremia are expressed as mean ± SD. Sex, race and route of transmission were compared using Fisher exact test. Pairwise comparisons of CD4 and viremia for early phases were performed using unpaired Student’s t tests. Comparisons among all groups (age at first visit, CD4 and viremia in the chronic phase and nadir CD4) were performed with the one-way analysis of variance test. MSM, men who have sex with men, HS, heterosexuals, IDU, intravenous drug users; n, numbers; NS, not significant; na, not available.
1 P = 0.004 and 0.05 for the comparison of age between rapid and viremic slow progressors, and classic and viremic slow progressors, respectively, as determined by the Mann-Whitney test.
2 P = 0.004 for the comparison of CD4+ T cells/mm3 in chronic phase between rapid progressors and aviremic slow progressors as determined by the Mann-Whitney test.
3 P = 0.0008 and 0.001 and 0.02 nadir CD4 for the comparison between rapid and classic progressors, rapid and viremic slow progressors, and rapid and aviremic slow progressors, respectively, as determined by the Mann-Whitney test.
4 50 copies/ml corresponds to the detection threshold of the viral load test.
5 P = 0.002 for the comparison of viremia in chronic phase between classic progressors and aviremic slow progressors as well as for rapid and aviremic slow progressors, as determined by the Mann-Whitney test.
6 P = 0.006, 0.0007, 0.0005, 0.0004 and 0.001 for the comparison of peak viremia between rapid progressors and viremic slow progressors, rapid progressors and aviremic slow progressors, classic progressors and viremic slow progressors, classic progressors and aviremic slow progressors, and viremic and aviremic slow progressors, respectively, as determined by the Mann-Whitney test.