Skip to main content
. Author manuscript; available in PMC: 2017 May 1.
Published in final edited form as: Cancer Res. 2016 Apr 20;76(9):2500–2506. doi: 10.1158/0008-5472.CAN-15-2733

Table 2.

Mitochondrial sirtuins: Metabolic substrates, functions, downstream targets, and expression pattern in various cancers*

Sirtuin Activity Substrates Functions Downstream
targets		 Relative
expression in
various cancer
SIRT3

  • Deacetylates

 AceCS2,
IDH2,
GDH,
MCP1,
PDH,
MnSOD,
OGG1,
GOT2,
FOXO3a,
Skp2		 Metabolism/gene
transcription/
apoptosis/ DNA
repair/ oxidative
stress		 PGC-1α,
Notch-1,
HIF1-α,
GSK-
3β/Bax,
NMNAT2,
PI3K/Akt,
NF-κB, p53,
p21, Ku70

  • Downregulated in gastric cancer, B cell malignancies, HCC, NSCLC, prostate cancer, breast cancer, pancreatic cancer

  • Upregulated in breast cancer, melanoma, colon cancer, OSCC, lung adenocarcinoma
SIRT4

  • ADP ribosyltransferase

  • Lipoamidase

  • Biotinidase

 GDH Metabolism E-cadherin

  • Downregulated in B cell lymphoma, breast cancer, HNSCC, colorectal cancer, lung tumors in mice, gastric adenocarcinoma
SIRT5

  • Lysine desuccinylase,

  • Demalonylase,

  • Deglutarylase,

  • Deacetylates

 CPS1,
PML		 Metabolism Nrf2

  • Downregulated in HNSCC, leukemia

  • Upregulated in NSCLC
*

This table provides examples that have been studied in a greater detail. It is by no means a complete depiction of all the substrates, functions, downstream targets, and expression pattern in cancer.