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. Author manuscript; available in PMC: 2016 Jun 28.
Published in final edited form as: Leukemia. 2015 Dec 28;30(5):1086–1093. doi: 10.1038/leu.2015.350

Figure 3. Dexamethasone synergizes with venetoclax through the induction of Bcl-2 and Bim.

Figure 3

A. MM.1s and KMS18 were treated with the indicated concentrations of venetoclax (Ven) and dexamethasone alone or in combination for 24 h. Real-time PCR was performed on cDNA generated from RNA isolated from control and treated samples. The data are presented as the means (±SE) of 3 independent experiments. B. Protein lysates were obtained from MM.1s and KMS18 6 and 24 h following treatment in A. Twenty μg of proteins were subjected to Western blotting and membranes probed with anti-Mcl-1, anti-Bcl-xL, anti-Bcl-2, anti-Bim, anti-Noxa, and anti-β-Actin antibodies. Blots are representative of two experiments.