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. Author manuscript; available in PMC: 2016 Jun 28.
Published in final edited form as: Leukemia. 2015 Dec 28;30(5):1086–1093. doi: 10.1038/leu.2015.350

Figure 4. Co-treatment of MM.1s and KMS18 cell lines with venetoclax and dexamethasone induces changes in the pattern of Bim binding to anti-apoptotic proteins, resulting in apoptosis.

Figure 4

Lysates were obtained from A. MM.1s or B. KMS18 and protein subjected to co-immunoprecipitation and input Western blot analysis as described in Fig. 1. Densitometry measurements of the Bim bound to Mcl-1, Bcl-xL, and Bcl-2 under each treatment condition, as described in Fig. 2. A. MM.1s control = 1.00, Dex = 1.48, Venetoclax = 1.07, Combination = 0.89. B. KMS18 control = 1.00, Dex = 1.2, Venetoclax = 1.09, Combination = 0.65. Blots are representative of at least four experiments, densitometry average of two experiments.