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. 2016 May 11;283(1830):20160151. doi: 10.1098/rspb.2016.0151

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© 2016 The Authors.

Published by the Royal Society under the terms of the Creative Commons Attribution License http://creativecommons.org/licenses/by/4.0/, which permits unrestricted use, provided the original author and source are credited.

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Figure 3. — Evolutionary divergence does not predict epistasis. (a) Phylogeny of the eight ancestral strains of Pseudomonas. Branch lengths are proportional to evolutionary distance. (b) The contrast in the fitness effect of rifampicin resistance mutations between tips or nodes on the phylogeny shown as a function of evolutionary distance. We find no evidence that rifampicin resistance mutations have more divergent effects on fitness between distantly related bacterial strains than between closely related strains.