Table 2.

Reaction optimization for aliphatic substrates.^[a]

Entry	Substrate	Temp [°C]	Product	Yield [%][b]	e.r.[d]
1	E-1c-Br	−30	a-2c-OMe-Br	92[c]	81:19
2	E-1c-NO2	−30	a-2c-OMe-NO2	86	87:13
3	Z-1c-NO2	−30	s-2c-OMe-NO2	87	99.5:0.5
4	Z-1c-NO2	24	s-2c-OMe-NO2	75	97:3
5[e]	Z-1c-NO2	−30	s-2c-OMe-NO2	79	97:3

^[a]The r.r. (defined as ratio of 2:5, see Table 4) was more than 20:1 and d.r. was more than 99:1 in all instances.

^[b]Determined by NMR using MTBE as added external standard.

^[c]5% of cyclized product was also seen by NMR.

^[d]Determined by chiral-phase HPLC.

^[e]2 mol% catalyst was used.