. Author manuscript; available in PMC: 2016 May 20.

Published in final edited form as: J Am Coll Cardiol. 2015 Mar 10;65(9):931–941. doi: 10.1016/j.jacc.2014.12.036

TABLE 2.

Hemodynamic Definitions for CLI

Patients With Tissue Loss	Patients With Ischemic Rest Pain
Ankle pressure <70 mm Hg	Ankle pressure <50 mm Hg
Toe pressure <50 mm Hg	Toe pressure <30 mm Hg
TcPO₂ <40 mm Hg	TcPO₂ <20 mm Hg
Skin perfusion pressure <40 mm Hg	Skin perfusion pressure <30 mm Hg (23)

The PARC group provided hemodynamic support for the definition of CLI. Atypical leg symptoms are symptoms that are worsened by exertion, but that do not meet the classic definition of intermittent claudication. These patients should have objective/confirmed evidence of PAD by noninvasive testing.

CLI = critical limb ischemia; PAD = peripheral arterial disease; PARC = Peripheral Academic Research Consortium; TcPO₂ = transcutaneous oxygen pressure.