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. Author manuscript; available in PMC: 2017 Jun 1.
Published in final edited form as: Am J Transplant. 2016 Mar 25;16(6):1726–1738. doi: 10.1111/ajt.13688

Figure 3. Kidney transplants in sensitized NHP with T cell depleting rhesus anti-CD4 and anti-CD8 mAb induction - DEPL-group.

Figure 3

A) Scheme and dosing strategy. B) Numbers of lymphocytes, T, B and NK cells after depletion with anti-CD4 and anti-CD8 antibodies (p-values show differences at time points prior and the first week after depletion; paired t-test). C) Mean survival time after depletion compared to basiliximab induction. D) (boxes represent scale bars): Histologic phenotype after rejection: i) peritubular capillaritis (PAS, arrow at inflammatory cells in PTC); ii) C4d staining of peritubular capillaries (arrows at staining of C4d deposition in PTC wall); iii) glomerulitis (H&E, arrow at inflammatory cell in capillary); iv) thrombotic microangiopathy [TMA] (Masson’s Trichrome, arrow at fibrin thrombi). NHP, nonhuman primates; mAb, monoclonal antibody; PTC, peritubular capillary