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. Author manuscript; available in PMC: 2016 May 21.
Published in final edited form as: ACS Chem Biol. 2016 Mar 2;11(5):1313–1321. doi: 10.1021/acschembio.6b00167

Figure 5.

Figure 5

Effects of varying cellular levels of LEDGF/p75 on BI/D potency in target cells. HEK293T cells were incubated with indicated concentrations of BI/D and then infected with VSV-G pseudotyped HIV-1 virions equivalent to 0.02 pg of p24 per cell. (A) Dose-dependent curves for BI/D activity in HEK293T LEDGF/p75 KO cells (black squares, data from ref 34), HEK293T cells transfected with either empty vector control (red circles) or with the plasmid that ectopically expresses HA-LEDGF/p75 (blue triangles). (B) Summary of the results depicted in A. *Data from ref 34.