Table 3. Odd ratios of hypertension associated with doubling (100% increment in) high sensitivity C-reactive protein levels in postmenopausal CARDIA women at year 25 according to early menopause status.

Category	No. of sample (%)	Odd ratios	95% CI	p-values
Early menopause present	119 (19.3)
Model 1		1.64	1.28 - 2.09	<0.001
Model 2		1.55	1.18 - 2.03	0.002
Model 3		1.49	1.10 - 2.02	0.010
Model 4		1.52	1.07 - 2.17	0.020
Model 5		1.32	0.87 - 1.99	0.192
Model 6		1.32	0.86 - 2.01	0.225
Early menopause absent	499 (80.7)
Model 1		1.37	1.24 - 1.52	<0.001
Model 2		1.25	1.11 - 1.39	<0.001
Model 3		1.22	1.08 - 1.37	0.001
Model 4		1.18	1.03 - 1.34	0.018
Model 5		1.04	0.89 - 1.22	0.633
Model 6		1.04	0.89 - 1.22	0.632

Model 1: Unadjusted analysis

Model 2: Model 1 adjusted for age and race

Model 3: Model 2 plus years of schooling, smoking, physical activity, alcohol use and center

Model 4: Model 3 plus total cholesterol, high density lipoprotein-cholesterol, diabetes, cholesterol lowering medication use and parity

Model 5: Model 4 plus body mass index

Model 6: Model 5 plus menopausal hormone therapy use and presence of hot flashes

This analysis included women with natural menopause and surgical menopause with bilateral oophorectomy. Early menopause was present if menopause occurred before 45 years of age. Hs-CRP was measured in microgram/ml.