Table 2.
Distribution of urinary concentrations of phthalate metabolites in CHAMACOS mothers during pregnancy (1999–2000)
| Phthalate metabolite (μg/g creatinine) | %>LODa | 13 weeks (n=350) | 26 weeks (n=339) | ICC (95%CI) | ||||
|---|---|---|---|---|---|---|---|---|
|
| ||||||||
| median(IQR) | min | max | median(IQR) | min | max | |||
| LMW | ||||||||
| MEP | 99.7 | 167.2(70.6-447.8) | 10.9 | 41791.0 | 166.1(65.6-396.3) | 0.6 | 9909.7 | 0.42(0.34,0.51) |
| MBP | 99.3 | 18.4(9.3-38.3) | 0 | 428.6 | 24.5(12-43.5) | 1.2 | 1282.2 | 0.02(0.00,0.92) |
| MiBP | 93.5 | 2.4(1.1-4.4) | 0 | 82.6 | 2.8(1.5-5.2) | 0 | 254.0 | 0.08(0.02,0.26) |
| ΣLMW | 220.2(107.0-533.9) | 14.2 | 45921.0 | 224.6(114.7-476.4) | 8.9 | 10885.0 | 0.42(0.33,0.51) | |
| DEHP | ||||||||
| MEHP | 89.6 | 3.1(1.4-6.7) | 0 | 272.3 | 3.7(1.9-6.9) | 0 | 104.4 | 0.06(0.01,0.30) |
| MEHHP | 99.4 | 12.8(6.6-24.6) | 0.7 | 846.7 | 15.9(8.7-28.6) | 0.2 | 865.7 | 0.07(0.01,0.28) |
| MEOHP | 98.3 | 8.7(4.7-15.9) | 0.1 | 630.2 | 12.6(6.9-22.2) | 0.1 | 651.6 | 0.06(0.01,0.28) |
| MECPP | 100.0 | 22.0(13.8-38) | 1.3 | 1135.6 | 26.9(17.4-48.5) | 5.2 | 1222.1 | 0.05(0.01,0.31) |
| ΣDEHP | 45.7(27.8-84.8) | 4.7 | 2798.3 | 59.5(35.3-104.6) | 7.9 | 2789.2 | 0.06(0.01,0.29) | |
| HMW | ||||||||
| MBzP | 98.3 | 6.4(3.3-12.4) | 0.3 | 133.0 | 7.6(4.4-13.9) | 0 | 168.6 | 0.32(0.23,0.42) |
| MCPP | 90.5 | 1.8(1.0-2.9) | 0 | 56.6 | 2.1(1.2-3.5) | 0 | 16.8 | 0.11(0.04,0.26) |
| MCOP | 96.4 | 2.8(1.7-4.4) | 0 | 162.3 | 3.2(1.9-5.1) | 0 | 33.2 | 0.01(0.00,1.00) |
| MCNP | 96.1 | 1.7(1.0-2.5) | 0.1 | 51.2 | 1.9(1.2-2.8) | 0 | 16.2 | 0.17(0.09,0.29) |
| ΣHMW | 66.0(37.4-107) | 8.4 | 2814.5 | 81.3(48.8-130.2) | 11.5 | 2807.6 | 0.06(0.01,0.29) | |
All measures were creatinine adjusted.
ICC - Intraclass Correlation Coefficient
LMW - low molecular weight
HMW - high molecular weight
a
LODs in μg/L are: MEP 0.6, MBP 0.4, MiBP 0.2, MEHP 0.5, MEHHP 0.2, MEOHP 0.2, MECPP 0.2, MBzP 0.3, MCPP 0.2, MCOP 0.2, MCNP 0.2