Table 5.

Differences in repeat element methylation associated with a 10-fold increase in prenatal phthalate metabolite concentration during late pregnancy (26 weeks gestation, 1999–2000)

Phthalate metabolite (μg/L)	Cord (n=239)				9 yr (n=243)
	Alu		LINE-1		Alu		LINE-1
	beta(95%CI)	p-val	beta(95%CI)	p-val	beta(95%CI)	p-val	beta(95%CI)	p-val
LMW
MEP	−0.16(−0.31, −0.02)	0.025	−0.20(−0.52,0.11)	0.197	−0.02(−0.18,0.13)	0.761	−0.09(−0.39,0.21)	0.571
MBP	−0.12(−0.32,0.07)	0.225	−0.06(−0.48,0.36)	0.788	−0.07(−0.29,0.14)	0.490	0.07(−0.34,0.48)	0.753
MiBP	−0.14(−0.30,0.02)	0.093	−0.17(−0.52,0.17)	0.330	−0.24(−0.41, −0.07)	0.006	0.21(−0.13,0.54)	0.225
ΣLMW	−0.19(−0.36, −0.02)	0.025	−0.25(−0.61,0.11)	0.173	−0.05(−0.23,0.13)	0.613	−0.06(−0.41,0.28)	0.731
DEHP
MEHP	−0.01(−0.18,0.15)	0.878	−0.09(−0.45,0.27)	0.616	−0.18(−0.35, −0.02)	0.032	0.18(−0.14,0.51)	0.271
MEHHP	−0.06(−0.26,0.13)	0.525	0.00(−0.42,0.42)	0.995	−0.27(−0.47, −0.08)	0.006	0.22(−0.16,0.61)	0.252
MEOHP	−0.05(−0.24,0.14)	0.627	0.09(−0.32,0.5)	0.662	−0.30(−0.50, −0.11)	0.003	0.27(−0.12,0.65)	0.181
MECPP	−0.02(−0.28,0.23)	0.870	0.09(−0.45,0.63)	0.753	−0.2(−0.45,0.06)	0.128	0.10(−0.4,0.59)	0.701
ΣDEHP	−0.04(−0.27,0.2)	0.759	0.06(−0.44,0.56)	0.807	−0.26(−0.49, −0.02)	0.033	0.18(−0.28,0.64)	0.439
HMW
MBzP	−0.05(−0.24,0.14)	0.598	−0.22(−0.62,0.18)	0.275	−0.13(−0.32,0.06)	0.168	0.07(−0.29,0.42)	0.714
MCPP	0.00(−0.18,0.18)	0.979	−0.22(−0.6,0.15)	0.244	−0.06(−0.23,0.12)	0.515	0.16(−0.18,0.5)	0.367
MCOP	−0.02(−0.20,0.17)	0.845	−0.20(−0.6,0.21)	0.342	−0.20(−0.39,0.00)	0.053	0.41(0.03,0.79)	0.037
MCNP	−0.01(−0.22,0.19)	0.897	−0.38(−0.82,0.06)	0.089	0.08(−0.17,0.34)	0.516	0.62(0.14,1.1)	0.012
ΣHMW	−0.02(−0.27,0.24)	0.896	−0.02(−0.57,0.52)	0.929	−0.30(−0.55, −0.04)	0.024	0.21(−0.3,0.71)	0.429

All models adjusted for creatinine as a covariate in the model. The cord Alu model also controlled for maternal pre pregnancy BMI.

All phthalate concentrations were log 10 transformed and low non detects were imputed

LMW - low molecular weight

HMW - high molecular weight