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. Author manuscript; available in PMC: 2017 Jun 1.
Published in final edited form as: J Hepatol. 2016 Feb 24;64(6):1295–1304. doi: 10.1016/j.jhep.2016.02.024

Figure 6.

Figure 6

Overexpression of Per1 inhibits tumor growth in xenograft model. [A] There was a significant inhibition in tumor growth in nude mice injected with Per1 overexpressing cells. Three representative tumors from both the EV and Per1 OE group and a summary graph of data time points are shown. Data are mean ± SEM of tumor size evaluations from 8 mice per each group of animals. *p<0.05 vs. the corresponding values of tumor volume in the EV group. [B] Overexpression of Per1, decreased proliferation (by PCNA), inhibition of angiogenesis factors (VEGF-A, NGF), EMT-related genes (TIMPs and MMPs) and a metastasis markers (S100A4) are shown by q-PCR in tumor tissue of the Per1 OE group. Data are mean ± SEM for 3 different tissue samples. [C] Decreased PCNA, fibronectin and VEGF expression are shown by IHC in the Per1 OE group. Original magnification: 20X.

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