Table 5.

12-month change [SE] in sex hormones in women randomized to 2000 IU vitamin D/day or placebo: women with complete pill counts [N=120].

	12-Month Change (Mean [SE])
	Placebo [N=61]	Vitamin D [N=59]	pa	pb	Pc
Estrone [pg/mL]	−3.15 [1.04]	−3.87 [1.06]	0.50	0.39	0.32
Estradiol [pg/mL]	−1.04 [0.33]	−1.91 [0.32]	0.04	0.04	0.07
Free Estradiol [pg/mL]	−0.04 [0.01]	−0.07 [0.01]	0.008	0.01	0.02
Bioavailable Estradiol [pg/mL]	−0.99 [0.24]	−1.73 [0.24]	0.01	0.01	0.02
Testosterone [ng/dL]	−1.25 [0.55]	−1.23 [0.72]	0.95	0.48	0.72
Free Testosterone [pg/mL]	−0.55 [0.12]	−0.75 [0.13]	0.15	0.28	0.29
Bioavailable Testosterone [ng/dL]	−1.31 [0.29]	−1.83 [0.33]	0.14	0.23	0.25
SHBG [nmol/L]	6.35 [0.17]	11.64 [1.61]	0.009	0.005	0.03

^aGEE model comparing the 12-mo change between vitamin D vs. placebo; all available data, unadjusted.

^bAdjusted for age, race/ethnicity, baseline serum 25[OH]D and baseline BMI.

^cAdjusted for age, race/ethnicity, baseline serum 25[OH]D, baseline BMI, vitamin D intake [diet + non-study supplements], average sun exposure [hrs/d], and total 12-month weight loss.