TABLE 3.
Mean scores and standard errors on secondary outcomes
| Study Visit Monthb |
||||||
|---|---|---|---|---|---|---|
| Outcome | Initial Visita | 2 | 6 | 12 | P-value 6 vs 12 Months | |
| Hot Flash Related Daily Interference Scale | Acupuncture | 44.44 (1.86) | 28.01 (1.67) | 28.27 (1.73) | 27.16 (1.76) | 0.53 |
| Control | 41.24 (3.66) | 48.65 (3.54) | 47.08 (3.68) | 26.83 (3.68) | <.001 | |
| Diff P-valuec | 0.46 | <.001 | <.001 | 0.93 | ||
| CESD | Acupuncture | 8.05 (0.41) | 7.44 (0.35) | 7.62 (0.36) | 7.31 (0.37) | 0.39 |
| Control | 7.77 (0.78) | 8.79 (0.73) | 8.97 (0.75) | 7.38 (0.75) | 0.03 | |
| Diff P-value | 0.76 | 0.10 | 0.10 | 0.93 | ||
| WHQ Depression | Acupuncture | 0.17 (0.01) | 0.16 (0.01) | 0.18 (0.01) | 0.16 (0.02) | 0.20 |
| Control | 0.22 (0.04) | 0.13 (0.03) | 0.22 (0.03) | 0.13 (0.03) | 0.004 | |
| Diff P-value | 0.20 | 0.43 | 0.20 | 0.42 | ||
| WHQ Anxiety | Acupuncture | 0.23 (0.02) | 0.21 (0.03) | 0.19 (0.03) | 0.17 (0.03) | 0.54 |
| Control | 0.23 (0.04) | 0.35 (0.04) | 0.29 (0.05) | 0.21 (0.05) | 0.06 | |
| Diff P-value | 0.98 | 0.001 | 0.02 | 0.46 | ||
| WHQ Attractiveness | Acupuncture | 0.36 (0.03) | 0.36 (0.03) | 0.34 (0.03) | 0.35 (0.03) | 0.69 |
| Control | 0.37 (0.06) | 0.52 (0.05) | 0.40 (0.06) | 0.32 (0.06) | 0.24 | |
| Diff P-value | 0.80 | 0.01 | 0.30 | 0.72 | ||
| WHQ Somatic | Acupuncture | 0.38 (0.02) | 0.30 (0.02) | 0.33 (0.02) | 0.32 (0.02) | 0.8165 |
| Control | 0.43 (0.03) | 0.47 (0.03) | 0.49 (0.03) | 0.33 (0.03) | <.001 | |
| Diff P-value | 0.2426 | <.001 | <.001 | 0.83 | ||
| WHQ Memory | Acupuncture | 0.57 (0.03) | 0.43 (0.13) | 0.41 (0.13) | 0.42 (0.13) | 0.77 |
| Control | 0.51 (0.06) | 0.59 (0.13) | 0.60 (0.13) | 0.47 (0.13) | 0.01 | |
| Diff P-value | 0.39 | 0.004 | 0.001 | 0.33 | ||
| WHQ Sexuality | Acupuncture | 0.54 (0.03) | 0.48 (0.03) | 0.43 (0.03) | 0.45 (0.03) | 0.53 |
| Control | 0.55 (0.06) | 0.54 (0.05) | 0.56 (0.05) | 0.52 (0.05) | 0.46 | |
| Diff P-value | 0.89 | 0.29 | 0.04 | 0.27 | ||
| WHQ Vasomotor | Acupuncture | 0.94 (0.01) | 0.73 (0.03) | 0.77 (0.03) | 0.74 (0.03) | 0.22 |
| Control | 0.95 (0.02) | 0.93 (0.06) | 0.97 (0.06) | 0.70 (0.06) | <.001 | |
| Diff P-value | 0.87 | 0.001 | 0.002 | 0.59 | ||
| WHQ Sleep | Acupuncture | 0.50 (0.03) | 0.37 (0.02) | 0.42 (0.02) | 0.38 (0.02) | 0.21 |
| Control | 0.49 (0.05) | 0.55 (0.05) | 0.60 (0.05) | 0.45 (0.05) | 0.005 | |
| Diff P-value | 0.83 | <.001 | <.001 | 0.22 | ||
| Pittsburgh Sleep Score | Acupuncture | 9.85 (0.27) | 8.81 (0.22) | 9.22 (0.23) | 8.85 (0.23) | 0.14 |
| Control | 10.41 (0.68) | 10.90 (0.46) | 10.61 (0.48) | 9.02 (0.48) | 0.002 | |
| Diff P-value | 0.39 | <.001 | 0.01 | 0.75 | ||
| GAD7 | Acupuncture | 5.39 (0.41) | 4.17 (0.71) | 4.17 (0.71) | 4.15 (0.72) | 0.94 |
| Control | 4.56 (0.75) | 5.93 (0.91) | 5.64 (0.92) | 4.29 (0.92) | 0.06 | |
| Diff P-value | 0.38 | 0.01 | 0.05 | 0.84 | ||
| Perceived Stress Scale | Acupuncture | 4.30 (0.26) | 4.07 (0.22) | 4.34 (0.23) | 4.00 (0.24) | 0.15 |
| Control | 3.95 (0.53) | 5.28 (0.47) | 5.16 (0.49) | 3.77 (0.49) | 0.01 | |
| Diff P-value | 0.56 | 0.02 | 0.13 | 0.67 | ||
| PROMIS – Anxiety t-score | Acupuncture | 51.75 (0.65) | NA | 50.53 (0.62) | 49.77 (0.64) | 0.23 |
| Control | 50.35 (1.52) | NA | 53.17 (1.31) | 49.89 (1.31) | 0.01 | |
| Diff P-value | 0.37 | 0.07 | 0.93 | |||
| PROMIS – Depression t-score | Acupuncture | 49.30 (0.60) | NA | 48.77 (0.56) | 48.51 (0.57) | 0.67 |
| Control | 49.33 (1.35) | NA | 49.70 (1.17) | 48.08 (1.17) | 0.21 | |
| Diff P-value | 0.98 | 0.48 | 0.74 | |||
| PROMIS – Sleep t-score | Acupuncture | 55.72 (0.67) | NA | 52.83 (0.58) | 51.99 (0.59) | 0.17 |
| Control | 56.85 (1.19) | NA | 57.10 (1.22) | 51.78 (1.22) | <.001 | |
| Diff P-value | 0.46 | 0.002 | 0.87 | |||
| SF-36 PCS | Acupuncture | 53.62 (0.54) | NA | 53.59 (0.44) | 53.35 (0.45) | 0.61 |
| Control | 53.03 (1.18) | NA | 52.13 (0.91) | 53.31 (0.91) | 0.23 | |
| Diff P-value | 0.64 | 0.15 | 0.97 | |||
| SF-36 MCS | Acupuncture | 50.22 (0.69) | NA | 49.81 (0.84) | 50.60 (0.85) | 0.28 |
| Control | 49.59 (1.75) | NA | 47.36 (1.44) | 48.82 (1.44) | 0.33 | |
| Diff P-value | 0.70 | 0.10 | 0.23 | |||
| Global QOL | Acupuncture | 70.83 (1.49) | 73.49 (1.27) | 71.09 (1.31) | 69.77 (1.35) | 0.38 |
| Control | 67.42 (3.08) | 68.80 (2.65) | 67.61 (2.74) | 70.02 (2.74) | 0.44 | |
| Diff P-value | 0.32 | 0.11 | 0.25 | 0.93 | ||
WHQ, Women's Health Questionnaire; CESD, Center for Epidemiological Studies Depression Scale; GAD7, General Anxiety Disorder Scale; PROMIS, Patient Reported Outcomes Measurement Information System (t-score rescales raw score into a standardized score with mean=50 and standard deviation=10); PCS = Physical Component Summary; MCS = Mental Component Summary.
Values for initial visit are raw group means (standard error). T-tests were used for comparison between groups.
Values for other visits are lsmean (standard error). P-values are for difference between treatment arms at given time point. These are results from a repeated measures ANCOVA model adjusting for baseline value, site, acupuncture use prior to the study, use of hormone therapy medications, and baseline menopause status.
Diff P-value refers to difference between Acupuncture and Control Group.