Table 6.
Rates per node from the studies used in the meta-analysis. nd: not defined, na: not applicable
| Study (Ref.) | Fail SLN rate with both techniques (95 %CI) | Standard technique detection rate (95 %CI) | SPIO detection rate (95 %CI) | Rate difference [p-value] | Malignancy rate (95 %CI) | Malignant nodes detected by standard technique | Malignant nodes detected by SPIO technique | Rate difference for malignant nodes [p/value] | Malignant nodes detected by both techniques | Malignant nodes in which both techniques failed |
|---|---|---|---|---|---|---|---|---|---|---|
| Douek et al. [10] | 12.9 (9.8, 16.6) | 73.5 (68.9, 77.7) | 80.0 (75.7, 83.6) | 6.5 [0.03] | na | na | na | na | na | na |
| Thill et al. [11] | na | 91.8 (87.8, 94.5) | 97.3 (94.5, 97.7) | 5.5 [0.1] | 15.5 (11.6, 20.3) | 14.1 (10.4, 18.6) | 14.8 (11, 19.5) | 0.7 [0.9] | 14.1 (10.4, 18.6) | 1.4 (0.4, 3.7) |
| Rubio et al. [12] | na | 80.1 (75, 84.5) | 92 (88, 94.8) | 11.6 [<0.0001] | na | na | na | na | na | nd |
| Pineiro et al. [13] | 3.7 (2, 6.6) | 86.3 (81.9, 89.8) | 91 (87.2, 93.8) | 4.7 [0.08] | 23.8 (19.2, 28.8) | 20.3 (16.1, 25.2) | 21.5 (17.2, 26.5) | 0.6 [0.9] | 20.3 (16.1, 25.2) | 1.6 (0.6, 3.8) |
| Ghilli et al. [14] | nd | 94.7 (91.9, 96.7) | 95.8 (93.1,97.5) | 1.1 [0.6] | 20.3 (16.4, 24.7) | 19 (15.2, 23.3) | 19.2 (15.4, 23.6) | 0.2 [1] | 17.9 (14.2, 22.2) | nd |
| Hopeau et al. [15] | 0.5 (0.03,3.4) | 90.2 (85.2, 93,7) | 97.2 (93.7, 98.9) | 7 [0.005] | 28.5 (22.7, 35.1) | 25.2 (19.7, 31.7) | 28 (22.2, 34.7) | 2.8 [0.58] | 24.8 (19.3, 31.2) | 0.5 (0.03,3.4) |
| Nordic study | 3 (1.6, 5.3) | 91.3 (88,93.8) | 93.3 (90.3, 95.5) | 2 [0.35] | 16.9 (13.4, 21) | 15.6 (12.3, 19.6) | 15.4 (12.1, 19.4) | 0.2 [1] | 13.2 (10.1, 16.9) | 0.5 (0.1, 2) |
The denominator is always the total of nodes per study. 95 % CI: 95 % confidence intervals using the Wilson procedure with a correction for continuity. Rate differences are given as|Standard-SPIO|. Fisher’s exact test and p values are given. p values <0.05 are considered significant