Skip to main content
. Author manuscript; available in PMC: 2017 Jun 1.
Published in final edited form as: Bioorg Med Chem Lett. 2016 Apr 11;26(11):2616–2621. doi: 10.1016/j.bmcl.2016.04.023

Scheme 1.

Scheme 1

Synthesis of compounds 29 and 39. Reagents and conditions: (a) PhB(OH)2, Na2CO3, Pd(OAc)2, P(o-tolyl)3, DME/H2O (6:1), 80 °C, 3: 63%, 4: 52%, 5: not isolated; (b) H2 (balloon), Pd/C; (c) 1:1 6N HCl (aq)/1,4-dioxane, 29: 35%, 39: 25% (prep. HPLC purification).