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. Author manuscript; available in PMC: 2017 Jun 1.
Published in final edited form as: Bioorg Med Chem Lett. 2016 Apr 11;26(11):2616–2621. doi: 10.1016/j.bmcl.2016.04.023

Scheme 3.

Scheme 3

Synthesis of compounds 26, 27, 34–36, and 40. Reagents and conditions: (a) Zn, 1,2-dibromoethane, TMSCl, DMF, 60 °C for 30 min to activate zinc, then sonication with 14 for 30 min; (b) Pd2dba3, P(o-tolyl)3, DMF, rt, 42-57%; (c) H2 (balloon), Pd(OH)2/C, rt; (d) 1:1 6N HCl (aq)/1,4-dioxane, 60 °C, 1h, 28-91% (purification by prep. HPLC or crystallization).