Table 4.

Comparison of the performance characteristics of enzyme-linked immunosorbent assay (ELISA), line immunoassay (LIA) and lupus anticoagulant (LA) testing of this study investigating 61 patients with APS and 156 controls with previously published data comprising 85 patients with APS and 144 controls [17]

Cohorts		Sensitivity	95 % CI	Specificity	95 % CI	+LR	95 % CI	-LR	95 % CI
61 Patients with APS, 157 controls including 25 asymptomatic carriers	ELISA	75.4	62.7–85.5	74.0	66.1–80.9	2.9	2.1–4.0	0.3	0.2–0.5
	LIA*	86.9	75.8–94.2	78.8	71.2–85.1	4.1	3.0–5.7	0.2	0.1–0.3
85 Patients with APS, 144 controls [17]	ELISA	58.8	47.6–69.4	95.8	91.1–98.5	14.1	6.3–31.5	0.4	0.3–0.6
	LIA	67.1	56.0–76.9	96.5	92.1–98.9	19.3	8.1–46.3	0.3	0.2–0.5

*Anti-annexin V antibody data for patients with cytomegalovirus infection (n = 10) were excluded. CI confidence interval, LR likelihood ratio