Table 4.
Work productivity activity impairment questionnaire for rheumatoid arthritis (WPAI:RA) results at baseline, week 36, and change from baseline to week 36, according to week-36 concordance category
| All patients | Positive discordance (n = 187) | Concordance (n = 549) | Negative discordance (n = 18) | |||||
|---|---|---|---|---|---|---|---|---|
| Mean (SD) | Median (Q1, Q3) | Mean (SD) | Median (Q1, Q3) | Mean (SD) | Median (Q1, Q3) | P valuea | ||
| Activity impairment (n = 754) | Baseline, % | 51.1 (20.7) | 50.0 (40.0, 70.0) | 41.3 (19.2) | 40.0 (30.0, 50.0) | 42.8 (19.9) | 45.0 (30.0, 60.0) | <0.0001 |
| Week 36, % | 35.4 (20.8) | 30.0 (20.0, 50.0) | 15.1 (16.6) | 10.0 (0, 20.0) | 25.6 (21.2) | 20.0 (10.0, 50.0) | <0.0001 | |
| Δ Baseline to week 36 | −15.7 (24.5) | −10.0 (–30.0, 0) | −26.2 (21.7) | −30.0 (–0.0, –10.0) | −17.2 (25.9) | −10.0 (–30.0, 0) | <0.0001 | |
| Employed patients | Positive discordance (n = 76) | Concordance (n = 206) | Negative discordance (n = 5) | |||||
| Mean (SD) | Median (Q1, Q3) | Mean (SD) | Median (Q1, Q3) | Mean (SD) | Median (Q1, Q3) | P valuea | ||
| Impairment while working (n = 287) | Baseline, % | 50.0 (27.4) | 40.0 (30.0, 70.0) | 37.8 (25.5) | 30.0 (20.0, 50.0) | 42.0 (27.7) | 50.0 (20.0, 50.0) | 0.0026 |
| Week 36, % | 26.3 (18.7) | 20.0 (20.0, 40.0) | 10.7 (13.8) | 10.0 (0, 20.0) | 12.0 (13.0) | 10.0 (0, 20.0) | <0.0001 | |
| Δ Baseline to week 36 | −23.7 (29.9) | −20.0 (–0.0, 0) | −27.1 (26.4) | −20.0 (–40.0, –10.0) | −30.0 (23.5) | −20.0 (–50.0, –10.0) | <0.0001 | |
| Overall work impairment (n = 287) | Baseline, % | 54.6 (27.1) | 50.0 (33.2, 76.1) | 41.5 (27.2) | 40.0 (20.0, 60.0) | 43.7 (28.6) | 50.0 (20.0, 58.3) | 0.0019 |
| Week 36, % | 28.7 (20.6) | 20.0 (20.0, 40.0) | 12.2 (15.9) | 10.0 (0, 20.0) | 12.0 (13.0) | 10.0 (0, 20.0) | <0.0001 | |
| Δ Baseline to week 36 | −25.8 (30.9) | −20.1 (–45.0, –8.6) | −29.3 (27.4) | −22.0 (–46.7, –10.0) | −31.7 (25.4) | −20.0 (–58.3, –10.0) | <0.0001 | |
| Employed patients | Positive discordance (n = 74) | Concordance (n = 200) | Negative discordance (n = 5) | |||||
| Mean (SD) | Median (Q1, Q3) | Mean (SD) | Median (Q1, Q3) | Mean (SD) | Median (Q1, Q3) | p valuea | ||
| Work time missed (n = 279) | Baseline, % | 16.9 (30.2) | 0 (0, 17.2) | 10.7 (24.3) | 0 (0, 6.3) | 3.3 (7.5) | 0 (0, 0) | 0.1565 |
| Week 36, % | 5.9 (15.9) | 0 (0, 1.8) | 2.4 (11.0) | 0 (0, 0) | 0 (0) | 0 (0, 0) | 0.2608 | |
| Δ Baseline to week 36 | −11.0 (30.9) | 0 (–10.5, 0) | −8.2 (22.9) | 0 (–2.5, 0) | −3.3 (7.5) | 0 (0, 0) | 0.2608 | |
Activity impairment includes all patients who had both baseline and week 36 data for this parameter. The remaining WPAI parameters include only patients who were employed and had WPAI data at both baseline and week 36. A total of 305 patients were employed at both baseline and week 36; individual WPAI parameters differ due to missing baseline or week 36 values. Positive discordance: patient global assessment – physician global assessment ≥2. Negative discordance: patient global assessment – physician global assessment ≤ –2. Concordance: patient global assessment – physician global assessment = 0 or 1. Δ change; Q1 quartile 1, Q3 quartile 3. a P value for baseline is for one-way analysis of variance, and for week 36 it is for an analysis of covariance model adjusted for baseline of the parameter