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. 2016 May 20;17:26. doi: 10.1186/s12868-016-0260-0

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© The Author(s). 2016

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 4 — Levels of tryptophan, serotonin and dopamine and their metabolites in the hypothalamus. Effect of ip injection with TNFα, IL-6 or both on a 5-hydroxyindoleacetic acid (5HIAA), b Serotonin (5HT), c 3,4-dihydroxyphenylacetic acid (DOPAC), d Dopamine (DA) and e tryptophan (TRP). ^aSignificantly different from Control group (P < 0.05), ^bsignificantly different from TNF, IL-6 Low and IL-6 High group (P < 0.05). Data is expressed as mean ± SEM (n = 6)