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Upstream regulators in hypothalamus after ip injection with TNFα and IL-6
| Upstream regulators | |||||
|---|---|---|---|---|---|
| TNF | IL-6 low | IL-6 high | TNF + IL-6 low | TNF + IL-6 high | |
| Cytokines | IFNG | IFNG | |||
| IFNG | IFNG | IL6 | IL6 | ||
| IL6 | IL6 | PRL | PRL | IFNG | |
| TGFB1 | PRL | TGFB1 | TGFB1 | TGFB1 | |
| Enzymes | TGFBR1 | TGFBR1 | |||
| TGFBR1 | IKBKG | IKBKG | |||
| TGFBR1 | IKBKG | ALDH1A2 | ALDH1A2 | ||
| ALDH1A2 | PARP9 | PARP9 | PARP9 | TGFBR1 | |
| Transcription factors | SRF | ||||
| MKL1 | SRF | ||||
| SRF | SMAD7 | MKL1 | |||
| MKL1 | SMAD7 | CEBPB | CEBPB | SRF | |
| STAT1 | CEBPB | STAT1 | STAT1 | MKL1 | |
| IRF3 | IRF3 | IRF3 | IRF3 | SMAD7 | |
