Table 3.
Clinical and Pathological Features in Nine Cases of Bladder Cancer with PNS
| Case No. | Author | Year | Age/Gender | Stage | Pathology | Clinical syndromes | Antibody | Treatment | Prognosis |
|---|---|---|---|---|---|---|---|---|---|
| 1 | Gita et al.[17] | 2015 | 73/F | Ma | Poorly differentiated carcinoma with squamous features | PEM | Negtive | Surgical resection and immunosuppression | Partial improvement |
| 2 | Syuichi et al.[12] | 2013 | 66/M | N/A | Urothelial carcinoma | PCD | Anti-CKB | TURBT | No improvement |
| 3 | Lukacs et al.[20] | 2012 | 76/F | pTa | Urothelial carcinoma | PEM and SSN | Anti-Hu | TURBT | Partial improvement |
| 4 | Forte et al.[21] | 2009 | 76/M | pT2 | High grade urothelial carcinoma | Neuromyotonia | Anti-VGKC | Resectionofthetumour | Complete improvement |
| 5 | Sean et al.[14] | 2003 | 59/M | N/A | N/A | POM | Anti-Ri | N/A | N/A |
| 6 | Charles et al.[22] | 2001 | 57/M | pT3 | High grade urothelial carcinoma | POM | Anti-Ri | Radical cystectomy and immunosuppression | Partial improvement |
| 7 | Lowe et al.[23] | 1992 | 71/M | pT3 | High grade urothelial carcinoma | Visual changes, glossal spasm and dysphagia | N/A | Combination chemotherapy | Complete improvement |
| 8 | John et al.[11] | 1999 | 64/F | pT2 | High grade urothelial carcinoma | PCD | Anti-Yo | Partial resection of the bladder | No improvement |
| 9 | Current report | 2015 | 68/M | pCIS | High grade urothelial carcinoma and the well-differentiated squamous cell carcinoma | PCD | Negtive | Laparoscopic radical cystectomy | Complete improvement |
aA recurrent pelvis mass proven as urothelial carcinoma 22 years after radical cystectomy; PEM Paraneoplastic encephalomyelitis; PCD Paraneoplastic cerebellar degeneration; SSN Subacute sensory neuronopathy; POM Paraneoplastic opsoclonus-myoclonus; Anti-CKB anti-creatine kinase, brain-type; N/A Not available