Table 2.

Univariable analysis of potential preditive factors of progression-free survival

	Univariable analysis				Multivariable analysis
Variable	HR	95 % CI	p	Median PFS [m]	HR	95 % CI	p
Age (< vs. > = median of 61 years)	1.08	0.75–1.55	0.69	6 vs. 6	–	–	–
Gender (m vs. f)	0.68	0.46–1.01	0.05	6 vs. 9	0.57	0.35–0.92	0.022 (*)
KPS (< vs. > = median of 70 %)	0.5	0.34–0.72	<0.001 (*)	4 vs. 9	0.5	0.33–0.78	0.002 (*)
MGMT-status (methylated vs. unmethylated)	1.46	0.97–2.2	0.07	9 vs. 6	1.61	1.03–2.52	0.036 (*)
Localization (other vs. central)	1.51	0.76–3	0.24	6 vs. 5	–	–	–
PTV (< vs. > = median of 337 ccm)	1.13	0.79–1.62	0.51	7 vs. 6	–	–	–
Subtotal resection or biopsy vs. gross total resection	0.71	0.49–1.02	0.07	4 vs. 8	–	–	–
Fractionation regimen (NFRT vs. AHFRT)	1.01	0.95–1.01	0.95	7 vs. 6	–	–	–

(*) p-value ≤ 0.05, HR hazard ratio, CI confidence interval, PFS progression-free survival, KPS Karnofsky performance status, MGMT O-6-methylguanine-DNA methyltransferase, PTV planning target volume, NFRT normofractionated radiotherapy, AHFRT accelerated hyperfractionated radiotherapy