Table 3.

Univariable analysis of potential preditive factors of overall survival

	Univariable analysis			Multivariable analysis
Variable	HR	95 % CI	p	Median OS [m]	HR	95 % CI	p
Age (< vs. > = median of 61 years)	1.18	0.8–1.7	0.4	14 vs. 12	–	–	–
Gender (m vs. f)	0.62	0.4–0.95	0.028 (*)	11 vs. 16	0.64	0.38–1.08	0.095
KPS (< vs. > = median of 70 %)	0.96	0.94–0.98	<0.001 (*)	9 vs. 15	–	–	–
MGMT-status (methylated vs. unmethylated)	1.68	1.08–2.61	0.021 (*)	16 vs. 11	1.89	1.158–3.09	0.011 (*)
Localization (other vs. central)	1.71	0.83–3.56	0.15	13 vs. 13	–	–	–
PTV (< vs. > = median of 337 ccm)	1.37	0.93–2.02	0.11	14 vs. 12	1.61	1–2.6	0.048 (*)
Subtotal resection or biopsy vs. gross total resection	0.64	0.43–0.95	0.025 (*)	11 vs. 15	0.62	0.39–0.98	0.041 (*)
Fractionation regimen (NFRT vs. AHFRT)	1.16	0.79–1.71	0.46	15 vs. 10	–	–	–

(*) p-value ≤ 0.05, HR hazard ratio, CI confidence interval, OS overall survival, KPS Karnofsky performance status, MGMT O-6-methylguanine-DNA methyltransferase, PTV planning target volume, NFRT normofractionated radiotherapy, AHFRT accelerated hyperfractionated radiotherapy