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. Author manuscript; available in PMC: 2017 May 1.
Published in final edited form as: Matrix Biol. 2016 Jan 18;52-54:355–362. doi: 10.1016/j.matbio.2016.01.005

Figure 2. The core-domain structure of syndecans.

Figure 2

The extracellular domain is depicted in red and both heparan and chondroitin sulphate chains are indicated by the blue lines. Cleavage sites are indicated by purple blocks, followed by a short transmembrane domain in blue. Each syndecan has a short cytoplasmic domain in which a variable region is flanked by two highly conserved regions termed C1 and C2. Cleavage of the ectodomain can occur via numerous metalloproteinases such as MMP2, 3, 7 and 9, as well as proteases thrombin and plasmin. HS, Heparan sulphate; CS, Chondroitin sulphate; SDC, syndecan; TM, transmembrane.