Skip to main content
. Author manuscript; available in PMC: 2017 Jun 1.
Published in final edited form as: J Immunol. 2016 Apr 25;196(11):4487–4497. doi: 10.4049/jimmunol.1600141

Figure 7. IDO2 modulates a subset of B cell costimulatory markers in vitro.

Figure 7

A. wt and IDO2 ko splenocytes were cultured for 72h with anti-IgM or anti-CD40 + IL-21. Costimulatory molecules were upregulated relative to unstimulated C57BL/6 cells. Experiment was repeated 3 times with a representative experiment shown. dotted line = naïve B6, bold line = IDO2 wt at 72h, shaded = IDO2 ko at 72h. B. CD40 expression is significantly reduced in IDO2 ko B cells (n=6) relative to IDO2 wt (n=6). No differences were seen for any other measured marker. C. No differences in costimulatory markers were seen when IDO2 wt (n=3) or IDO2 ko (n=3) B cells were cultured 72h with anti-CD40 + IL-21. Data pooled from a minimum of two independent experiments. **=p<0.01. Not specified=not significant.